Marla Weetall Selected Research

PTC-028

12/2020	Efficacy of the novel tubulin polymerization inhibitor PTC-028 for myelodysplastic syndrome.
1/2020	The anti-mitotic agents PTC-028 and PTC596 display potent activity in pre-clinical models of multiple myeloma but challenge the role of BMI-1 as an essential tumour gene.
10/2018	Inhibition of BMI1, a Therapeutic Approach in Endometrial Cancer.

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Marla Weetall Research Topics

Disease

14	Neoplasms (Cancer) 01/2022 - 01/2016
9	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 12/2021 - 01/2016
4	COVID-19 02/2022 - 08/2020
3	Leukemia 01/2022 - 01/2019
3	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 12/2020
3	Inflammation (Inflammations) 01/2021 - 04/2003
2	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2021 - 01/2019
2	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2021 - 12/2020
2	Multiple Myeloma 01/2021 - 01/2020
2	Adenocarcinoma 01/2021 - 01/2019
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2017 - 05/2007
2	Infections 01/2017 - 07/2013
2	Hypoxia (Hypoxemia) 07/2016 - 01/2016
1	Disease Progression 12/2021
1	Huntington Disease (Huntington's Disease) 12/2021
1	Glioblastoma (Glioblastoma Multiforme) 10/2021
1	Leiomyosarcoma 10/2021
1	Diffuse Intrinsic Pontine Glioma 10/2021
1	Communicable Diseases (Infectious Diseases) 07/2021
1	Body Weight (Weight, Body) 01/2021
1	Neuromuscular Diseases (Neuromuscular Disease) 01/2021
1	Lymphoma (Lymphomas) 01/2020
1	Familial Dysautonomia (Riley Day Syndrome) 01/2019
1	Hematologic Neoplasms (Hematological Malignancy) 01/2019
1	Carcinosarcoma 10/2018
1	Endometrial Neoplasms (Endometrial Cancer) 10/2018
1	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 06/2018
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 06/2018
1	Phototoxic Dermatitis (Phototoxicity) 01/2017
1	Ovarian Neoplasms (Ovarian Cancer) 01/2017
1	Shock 01/2017
1	Virus Diseases (Viral Diseases) 07/2016
1	Muscular Atrophy (Muscle Atrophy) 03/2016
1	Retinal Diseases 01/2016
1	Retinal Degeneration 01/2016
1	Choroideremia 01/2016
1	Hepatitis C 03/2014
1	Chronic Hepatitis C 07/2013
1	Cystic Fibrosis (Mucoviscidosis) 05/2007
1	Experimental Arthritis 04/2003
1	Arthritis (Polyarthritis) 04/2003

Drug/Important Bio-Agent (IBA)

9	Proteins (Proteins, Gene)FDA Link 12/2021 - 05/2007
7	emvododstatIBA 02/2022 - 07/2016
7	Pharmaceutical PreparationsIBA 10/2021 - 05/2007
6	PTC596IBA 10/2021 - 06/2018
4	Dihydroorotate DehydrogenaseIBA 02/2022 - 01/2019
3	TubulinIBA 10/2021 - 12/2020
3	CytokinesIBA 01/2021 - 01/2016
3	PTC-028IBA 12/2020 - 10/2018
2	pyrimidineIBA 01/2022 - 01/2019
2	NucleotidesIBA 01/2022 - 01/2019
2	Antiviral Agents (Antivirals)IBA 07/2021 - 07/2013
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2019 - 01/2016
2	Nonsense Codon (Nonsense Mutation)IBA 01/2017 - 05/2007
2	atalurenIBA 01/2016 - 05/2007
2	6- (3- cyano- 6- ethyl- 5- fluoro- 1- (pyrimidin- 2- yl)- 1H- indol- 2- yl)- N- (1,1,1- trifluoropropan- 2- yl)pyridine- 3- sulfonamideIBA 03/2014 - 07/2013
1	GuanineIBA 12/2021
1	Adenine FDA LinkGeneric 12/2021
1	CytosineIBA 12/2021
1	Dacarbazine (DIC)FDA LinkGeneric 10/2021
1	Temozolomide (Temodar)FDA LinkGeneric 10/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	Proteasome InhibitorsIBA 01/2021
1	DNA (Deoxyribonucleic Acid)IBA 01/2021
1	RNA Precursors (Precursor, mRNA)IBA 01/2021
1	Tubulin ModulatorsIBA 12/2020
1	Phosphotransferases (Kinase)IBA 01/2019
1	Polycomb Repressive Complex 1IBA 01/2019
1	130-nm albumin-bound paclitaxelIBA 01/2019
1	Biological ProductsIBA 01/2019
1	EnzymesIBA 01/2019
1	Uracil NucleotidesIBA 01/2019
1	Stem Cell FactorIBA 10/2018
1	Paclitaxel (Taxol)FDA LinkGeneric 10/2018
1	Carboplatin (JM8)FDA LinkGeneric 10/2018
1	RisdiplamIBA 08/2018
1	Agammaglobulinaemia Tyrosine KinaseIBA 06/2018
1	ibrutinibIBA 06/2018
1	clitocineIBA 01/2017
1	Retinaldehyde (Retinal)IBA 01/2017
1	MyostatinIBA 03/2016
1	3' Untranslated Regions (3' UTR)IBA 01/2016
1	Messenger RNA (mRNA)IBA 01/2016
1	SulfonamidesIBA 03/2014
1	pyridineIBA 03/2014
1	IntegrinsIBA 04/2003
1	LipopolysaccharidesIBA 04/2003
1	Matrix Metalloproteinases (MMPs)IBA 04/2003
1	Collagen Type II (Type II Collagen)IBA 04/2003
1	Integrin alpha4beta1 (VLA-4)IBA 04/2003

Therapy/Procedure

14	Therapeutics 07/2021 - 07/2013
1	Transplantation 01/2019
1	Intramuscular Injections 03/2016
1	Oral Administration 01/2016